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Re: survivor1x post# 292047

Friday, 06/26/2020 5:48:45 PM

Friday, June 26, 2020 5:48:45 PM

Post# of 700872
Just a small point, survivor: Landmark survival should really be milestone survival.
They are used interchangeably somewhat, but there is a difference.

Milestone survival is defined as the Kaplan-Meier (27) survival probability at a time point defined a priori, such as two years. The word “milestone” is used in order to distinguish from that of “landmark.” The landmark method was first introduced by Anderson et al. (28) in an attempt to address the issue of bias in the analysis of survival when the covariate of interest is an on-study measurement such as tumor response status, ie, responders vs nonresponders. The landmark analysis excludes patients whose survival times did not exceed the fixed time point after initiation of therapy or random assignment. The survival curve using the landmark analysis will result in a plateau at 100% survival probability from time zero up to the chosen time point.



https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836810/
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