Amarin Corp Plc (AMRN)

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Table of Contents (until someone posts the full doc):

Hindsight Bias Clouded the District Court’s Consideration of Powerful Objective Indicia Evidence .................................................... 2 A. The District Court’s Premature Conclusion of Obviousness, Before Considering the Objective Indicia, Was Not Harmless Error ........................................... 2 B. Defendants’ Attempts to Justify the District Court’s Dismissal of Objective Indicia Evidence on Grounds Not Articulated by the District Court Should Be Rejected ............................ 7 II. Defendants Cannot Excuse the District Court’s Errors in Finding Motivation and Reasonable Expectation of Success .................................... 12 The District Court’s Extrapolation of the Effects of EPA in Patients with Mild to Moderately Elevated Triglycerides to Patients with Severe Hypertriglyceridemia Was Error.............................. 12

Page ii Defendants’ Attempts to Fill the Gap in the District Court’s Reasoning Fail ............................................................ 17 III. None of Defendants’ Alternative Grounds Merit Affirmance .................................................................. 26 A. The District Court Properly Found Infringement .............................................................. 26 B. Defendants’ Alternative Invalidity Arguments Are Waived ............................................ 28