NorthWest Biotherapeutics Inc (NWBO)

[sentiment_stocks]

Yes... you're right, likely hyper-progression is the reason it dropped.

Just have to point out the crossing curves and the excess mortality (well, actually, excess progression, seeing as this is labelled PFS) in the Nivo arm between about 3 months and 7 months.
You know what that is, don't you...

And we really don't know, but some (many now) of us suspect we may very well see (or have seen - depending upon a rework of the progression criteria and how that's crafted) a bit of a drop in the treatment arm on the PFS curves... however LL has made it rather clear that there is a group of patients who never progressed, and that will bring that curve back up and that will surely beat the control arm long term. I'll be curious as well to see if and how the non proportional hazards make their way into the SAP.

We won't have crossing survival curves, but we will have have curves that diverge more markedly beyond 24 months.
(Hence the median is not the best metric..)

Right, we won't see treatment cross below it. We may see treatment and control follow along closely to each other until they reach a certain point... maybe 24 months?... when they likely start to separate, although, we'll have to see.

Again, my point to ex was that he should very well know why this trial is took so long... and now it's taking longer due to Covid. And all of us have been impacted, in various ways, by this dreaded scourge, so it's completely reasonable that it would also effect, and unfortunately extend, the timeline readout for the DCVax-L trial. Data lock quite obviously coming, within days, or a week or two, with top line soon to follow.

So to keep hammering on that there will never be a data lock, or never be top line is simply a waste of our eyeball energy.