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Sunday, June 21, 2020 11:20:22 PM
Dr. Ethan Russo on the Entourage Effect
Dr. Ethan Russo is a neurologist who currently serves as the Director of Research and Development at the International Cannabis and Cannabinoids Institute in Prague.
In a 2019 interview, Russo redefined the phrase “entourage effect” from a scientific perspective, attempting to convey the significance and complexity of botanical synergy:
“A botanical doesn’t rely on one compound to produce the beneficial effects. Rather there may be many — and that’s certainly the case in cannabis where we know that there are actually over one-hundred related molecules, which we call cannabinoids, but in addition, there are aromatic compounds [called] terpenoids that alter the effects of the cannabinoids in a way that often is synergistic. Synergy is a boosting of effect. So, it would be the idea that 2 + 2, instead of equaling 4, gives you an 8 in terms of the benefit. . . .It is sort of like an ensemble of musical instruments where you might think of THC as the soloist with an important part provided by cannabidiol, but you also have these other components producing a harmony that really increases the overall effect…” (“Dr Ethan Russo: CBD, The Entourage Effect, and the MicroBiome”, 2019)
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