NorthWest Biotherapeutics Inc (NWBO)

[longfellow95]

Summary: the same mortality rate between treatment and control group.

But...

Investigators gave HCQ dose which considered to be fatal or near fatal, 2400 mg over 1st 24 h. Total dose was 9600 mg/10 days. It's highers that ever used and ~1800 mg/ day required immediate admission to Emergency department. Middle age and elderly patients with advanced stage of Covid, HTD, diatetes, low K and Mg, hypoxia, etc. even more vulnerable to overdose related deaths. At least some treatment group participants were killed by intentional overdose.

After extraction of their deaths, survivors from overdosing actually shows less mortality.

This research is executed on hospitalised patients. Patients which passed day 8 of the symptoms.
After day 8 there isn't one medicine that can cure patients.
Maybe blood plasma is possible.
IF this treatment was be done with patients before day 5 of the symptoms all patients would be cured in 5 days.
One thing is clear that professor Peter Horby don't know how aggressive this Covid-19 Coronavirus is after day 5. You expect that they first do a research of the timeline of the virus before you start treating patients with medicines.
My confidence in scientist weaken every day more

INTERVIEW EXCLUSIVE: Martin Landray, Recovery.

http://www.francesoir.fr/politique-monde/interview-exclusive-martin-landray-recovery-hydroxychloroquine-game-over-uk


FS: From the data you presented, it would appear that they are more elderly patients with higher level of pre existing conditions (25% diabetes, 25% heart conditions). Why ?


Comment: Very sick patients (mortality 24% in control group)- significantly higher than average hospital mortality across the world

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FS: Could you please precise what dosage of HCQ you gave to the patient ? and the results ?

ML: It is 2400 mg in the first 24 hours and 800 mg from day 2 to day 10. It is an 10 day course of treatment in total.

Comment: 2400 mg/24 h is between TD50 and LD50, fatal for up 5-10% of generally healthy people, for elderly, very sick with multiple comorbidities can cause at least 25% deaths in the treatment group.

FS: How did you decide on the dosage of HCQ ?
ML : The doses were chosen on the basis of pharmacokinetic modelling and these are in line with the sort of doses that you used for other diseases such as amoebic dysentery.

Comment 1. It's near fatal dose, No LD5-LD50 dose can be chosen for any reasons.
Comment 2. "amoebic dysentery" is not treated by hydroxychloroquine but hydroxyQUINOLINE.
It appears researches did not realize the difference and chose the dose based on hydroxyQUINOLINE.

FS: Are there any maximum dosage for HCQ in the UK?
ML: I would have to check but it is much larger than the 2400mg, something like six or 10 times that.

Comment:
Dr Landray states that max HCQ dose is 24 000?
Unbeliavable. 1800 mg/24 h requires URGENT admission.


End of the Road for HCQ in COVID-19- No. It's should be "end of the road" for whom who developed and approved this deadly protocol.

https://www.medpagetoday.com/infectiousdisease/covid19/86932

(Under comments).

These researchers chose a near fatal dose of HCQ, in very sick patients, who had been hospitalised and had symptoms beyond 8 days.

HCQ is best used for mild to moderate disease at a very small fraction of the dose used in this 'trial'.

The Surgisphere study was plain fraud. It didn't kill anybody.
This 'trial' gave very ill Covid patients, doses of HCQ that would be considered near fatal in a healthy individual.

The fallout from the Surgisphere paper will be as nothing compared to this.