Amarin Corp Plc (AMRN)

[sts66]

The Du Bench Order:

Du Bench Order 3/30:___________________________________
Mori reports that triacylglycerols (TGs) “decreased significantly by 18.4% with EPA
(P = 0.012) and by 20% with DHA (P = 0.003).” (Ex. 1538 at 3.) A POSA would consider
this difference in triglyceride reduction “indistinguishable and of no clinical significance.”
(ECF No. 367 at 740:1-13.) A POSA would likewise recognize that Mori teaches that “4
grams pure EPA could reduce triglycerides by about 20 percent.” (ECF No. 371 at
1826:24-1827:5.)
Mori also reports that “[s]erum LDL cholesterol increased significantly with DHA (by
8%; P = 0.019), but not with EPA (by 3.5%; NS),” (Ex. 1538 at 3), “strongly suggesting
that these two Omega-3 fatty acids could have distinct effects on LDL cholesterol levels”

Did Du copy/paste that directly from the defendant's brief? Unbelievable that she didn't know what "NS" stood for in a patent trial in which everything revolved around stat sig trial results! Hell, "NS" was in the Kura Table 3 too!