Amarin Corp Plc (AMRN)

[jessellivermore]

HK..Regardless of who the inventor was..and JZ was the main author of a lot of the patents..He was not the "Lone" believer that EPA could lower Trigs and not raise LDL-C...There were others including me that knew EPA could could lower trigs, and not increase LDL-C to any great degree...

What is a fair statement is very few people did believe and certainly most of those knowledgeable in the field did believe lowering trigs reflexively increased LDL-C..And this was predicted by the Friedewald equation..

To this very day it is not completely clear how EPA actually exerts its magic..The reason why lowering trigs should raise LDL-C levels has to do with the fact VLDL, the lipoprotein that conveys trig in the circulation is mainly APO-b..and so is LDL which conveys LDL-C (low density lipo protein cholesterol..Add to this VLDL also conveys some LDL-C...In real life physiology as the trig content of an VLDL particle drops the VLDL particle will convert into a LDL-C particle..This is reflected in the Friedewald Equation. So Du was very wrong about her conclusion.."More mysterious was how EPA could lower Trigs and not increase LDL-C..You will not find many explanations in the literature...

My own personal opinion is that lack LDL-C elevation is related to the anti inflammatory effects of EPA...What is know is both sugar and trig levels are controlled by by the activity of enzymes..Insulin for sugar and FAS (Fatty Acid Synthase) for trigs that increase the removal of these energy sources from the blood..Insulin activity is diminished by high Systemic Inflammation (SI) and so is FAS...So EPA's actions on SI could have a statin like effect. lowering both LDL-C and total Cholesterol...This also might be an explanation of the infamous mineral oil issue..The higher cholesterol levels in the mineral oil arm.. Might actually be a reduction of Cholesterol in the EPA arms.

Du's opinion that knowledgeable people knew EPA could lower Trigs and not substantially increase LDL-C is erroneous. There were a few people who did, but very few..It is still somewhat of a mystery...

":>) JL