NorthWest Biotherapeutics Inc (NWBO)

[sentiment_stocks]

alpha puppy... thank you for your very detailed analysis of the PFS arm. I liked the way you showed your work, as opposed to just dry words on a page.

You know, one little detail regarding the IMUC control arm that you used to represent the control arm in the DCVax trial... the control arm in the IMUC trial received autologous monocytes (basically unactivated dendritic cells) as their control-arm treatment. This means that the control arm you compared DCVax-L to received an added boost, if you will, which the DCVax-L control arm did not.

Dendritic Cell Immunotherapy Promising in HLA-A2-Positive Glioblastoma
An unexpected increase was reported for immune response in some control patients after treatment with unincubated dendritic cells, possibly suggesting that activated dendritic cells without peptide loading is immunologically active, Dr. Yu noted. The phase III trial uses autologous monocytes instead of activated dendritic cells, as a control-arm treatment.

https://www.cancernetwork.com/sno-2015/dendritic-cell-immunotherapy-promising-hla-a2-positive-glioblastoma

Just an interesting side-note.