NorthWest Biotherapeutics Inc (NWBO)

[skitahoe]

If you're looking for a covid-19 therapeutic, take a look at PSTI's PLX-PAD, it's going into Phase 2 Trials, but has given it to several ventilator patients and results to data are quite positive. One of the first eight did pass, 6 are out of the hospital. Ten additional patients will be reported on when they hit 28 days, I believe in the next week or so.

This drug has been in development for years, it's patents cover pneumonia, but the Phase 3 Trial is being done for CLI. I'll contend that a more effective use for the drug would be before ventilators are required, perhaps even before hospitalization is, but that's not where trials start. Patients on ventilators have roughly a 20% chance of survival, so even if the 7th patient of the eight fails to make it, 75% survival would be a huge improvement, and we've not heard more about the 7th patient.

In the case of the first American patient, it wasn't administered until his 22nd day on ventilator, he's gone home. I know of at least 4 more here in the U.S. under compassionate use terms, two are in the same hospital that did the first one, they have the drug as they're also participating in the CLI Trial. The drug is stored cryogenically. It's based on placental cells and 20,000 doses can be available from a single placenta. I believe they currently have the capacity to dose all those currently on ventilators, but I'm not certain of that fact.

Gary