Japanese influenzer with 7650 followers wrote on twitter:
May 19
Malavilok, already approved as an anti-HIV drug, appears to reduce the amount of virus as well as recovery. The theory behind the sudden emergence of CCR5 inhibitors is this.
May 19
1) Alveolar macrophages and airway cells produce a high level of RANTES by infectious stimuli, and the blocking of CCR5, which is the receptor of RANTES, suppresses the migration of immune cells to the lung, and overactivates them. 2) Could it be possible to block CCR5, which is the receptor of RANTES, to suppress the migration of immune cells to the lung and control the over-activation? This is a hypothesis.
Disruption of the CCL5 / RANTES-CCR5 Pathway Restores Immune Homeostasis and Reduces Plasma Viral ...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is now pandemic with nearly three million cases reported to date.
medrxiv.org
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May 19
---- Elevated IL-6 and CCL5 (RANTES), decreased CD8 cell count and SARS-CoV-2 viral hemorrhage were observed in 10 patients with severe COVID-19. The figure shows that not only IL-1, IL-6, and IL-8, but also RANTES also increased in relation to severity.
Following administration of the CCR5 inhibitor leronlimab, the CCR5 inhibitor can inhibit its action because it works in conjunction with complete inhibition of the CCR5 receptor in macrophages and T cells and - significant confirmation significant confirmation significant confirmation significant confirmation significant confirmation - confirmation confirmation - confirmation - confirmation - confirmation - confirmation
May 19
ANSWER TO.
@ influenzer3
The figure shows (a) a decrease in IL-6, (b) an increase in CD8 cells, and (c) the resulting normalization of the CD4/8 ratio over time after treatment.
May 19
Consistent with the decrease in IL-6, single cell RNA sequencing showed a decrease in cluster of myeloid cells expressing IL-6 and its related genes. This is a new approach to reduce viral hemorrhage by disrupting the CCL5-CCR5 axis through positive immunosuppression and immunization.
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