NorthWest Biotherapeutics Inc (NWBO)

[ae kusterer]

Please critique, with extreme prejudice, the analysis below:




David:Topline should come by 7/7/20. If it is strong , the nwbo market cap should be at least $5 billion($5.00 per share).





Frank:Why NWBO jumped 75 % on friday, 5/22/20:

1)Reardon et al at DFCI/Harvard/B and W announced in a 5/22/20 JAMA paper that BMS’s Opdivo was no better that Avastin(Novartis?/FDA approved) in GBM.JAMA Oncology
Source Reference: Reardon DA, et al "Effect of nivolumab vs bevacizumab in patients with recurrent glioblastoma: the CheckMate 143 phase 3 randomized clinical trial" JAMA Oncol 2020; DOI: 10.1001/jamaoncol.2020.1024.https://clinicaltrials.gov/ct2/show/NCT02017717?term=checkmate+143&draw=2&rank=1

2)a)Linda Liau(and her UCLA colleague scientist, Multuoglu) in a 5/22/20 JAMA accompanying editorial postulated that Opdivo would only be be better than Avastin in GBM if it was combined with Dc Vax L and ICLC, a TLR adjuvant.b)Reardon in a Medpage Today interview 5/22/20 said,” "Instead of PD-1 alone, we are probably going to need to give combination treatment to give the immune system a chance to fight the tumor."

Secondary Source
JAMA Oncology
Source Reference: Muftuoglu Y, Liau L "Results from the CheckMate 143 clinical trial: stalemate or new game strategy for glioblastoma immunotherapy?" JAMA Oncol 2020; DOI: 10.1001/jamaoncol.2020.0857.






(LL editorial published JAMA 5/22/20)

Miscellaneous field report on LL Keytruda combo work 5/24/20 : ("This trial(NCT04201873)just started in January. I know she had fantastic results with the poly iclc adjuvant(we have this paper/CR found). Combined with keytruda the results could be spectacular. She said it’s all in the timing. Gotta give the keytruda before surgery ."

Sent from my iPhone

On May 24, 2020, at 1:28 PM, Joseph H Pratt II <[e-mail]> wrote:

?
Harry:Do you know if Liau has seen results from the trial below(DC VAX L plus Keytruda)? Joe)

3)https://clinicaltrials.gov/ct2/show/NCT04201873?term=cloughesy&draw=2&rank=3. This is one supplementary nwbo trial I know about.There could be others in a clandestine state.In this trial Keytruda, ICLC, and DC Vax L are combo-ed.First patient dosed about 1/15/20, so Liau may know some results, but all is supposed to be secret , I think.




Chelsea Girls Questions:"Joe

Pls explain in one or two sentences

what is this in reference to

why is it important or critical, if it is

how does this trial impact nwbo

the Chelsea girls asked me about "supplementary trials" being run that would impact nwbo. I have no clue.

do you have an idea/?

thanks"