NorthWest Biotherapeutics Inc (NWBO)

[longfellow95]

Hi Sharpie.

Well, that's the final nail in the coffin for ICI's as monotherapies for GBM.
Did you notice that LL wrote the editorial on the trial, also released in JAMA today?
Full version only available to bona fide subscribers (unless you access it a different way..)

https://jamanetwork.com/journals/jamaoncology/article-abstract/2766209

So it was recurrent GBM and I'm not sure how you can have PFS with rGBM, but anyway, the Nivo arm was 1.5 months and the Bev arm was 3.5 months. Basically, extremely bad v very bad.
And on OS, Bev did slightly better than Nivo; 10.00 v 9.8 months.
And we already know the, ermm, limitations of Bev...

No reason to think that Pembro is any different or any better than Nivo.
Honestly, in our combo trial with Pembro, I expect L to do better than L plus Pembro.

LL is quoted as saying in the editorial:-

"The future of defeating this opponent will depend on a better elucidation of the mechanisms by which antitumor immune responses are generated in the central nervous system, as well as the identification of predictive biomarkers of response," they wrote. "It is anticipated that the next generation of clinical trials of immunotherapy for patients with glioblastoma would involve new strategies that build on the data and insights from the large multicenter phase 3 studies that have gone before."