Amarin Corp Plc (AMRN)

[jessellivermore]

Bill B

Quote: or example, "TRL in particular might be helpful in explaining the biologic effects of icosapent ethyl (Vascepa; Amarin) in reducing triglycerides, Pradhan explained. “In terms of unlocking the pathways that are involved, I think they can be very useful.”

The enigma here (why trig lowering doesn't always lower CVD event risk) is actually known to those with skill in the art..The issue is really that elevated trigs are almost always caused by elevated Systemic Inflammation (SI) and not by consuming too many trigs. Blood trig levels are not to a great degree related to excess intake..Elevated trigs are almost always caused by an inability to remove trigs from the bloodstream..The most important equation in Chemical Engineering is "Input minus output equals accumulation"..

.Everyone understands the problem in diabetes is lack of insulin or insulin activity results in elevated blood sugar.. Not because all diabetics have a sweet tooth. Insulin resistance (IR) is a condition seen in T2DMs (type 2 diabetics) IR is a condition where the insulin is not very effective at lowering blood sugar...IR is a direct result of evevated SI...

The same rules hold for elevated trigs ( I like to call this Trigabetes)...Fix the SI in T2DM and you fix the blood sugar..Fix the SI and you fix the trig levels...Dtrugs which lower trigs without lowering SI are not going to cut CVD event risk. That was the secret sauce that caused the R-I trial to be so successful..High trigs are a marker for high SI in most clinical situations...Its not the trigs that are going kill you..Its the high SI levels..

":>)JL