Amarin Corp Plc (AMRN)

[rmitra]

gg-
>1)~12.6% chance that EPA does NOT raise LDL levels given the data in Mori
>2) <5% chance that DHA does NOT raise LDL levels given the data in Mori?

Yes I think that is a reasonable "normal speak" summary.

>So a POSA should not expect EPA to be LDL neutral or lowering by just looking at Mori UNLESS he was only allowed to pick either DHA or EPA, and not any other potential molecules, to treat TG>500.

I'm not sure I understand the claim. What I would argue is that if I were a POSA who had just read Mori, it would not be obvious to me that it would be worth it to go through all of the trouble to purify EPA, when the evidence in Mori that EPA raises LDL levels LESS than DHA is not statistically significant, and it's quite possible, given the data in Mori that EPA raises LDL levels relative to placebo (12.6% chance). Then, on top of all that, I would worry about the relevance of Mori due to TG levels.

Basically I would think that EPA probably raises LDL levels just like DHA does, but that Mori, being a small study, was just underpowered to detect it at an alpha of 0.05. And then, I would say to myself, "and it's probably even worse that what I think, because that population didn't even really have people with HIGH TGs, which makes the problem worse"