Amarin Corp Plc (AMRN)

[rmitra]

Kura and Mori, Part II.

1. Mori does not teach that DHA raises LDL levels MORE than EPA.
2. Mori does teach that DHA raises LDL level relative to a placebo group with greater than 95% probability. (or more precisely, you can reject the null with >95% percent probability, which is a slightly different, but more accurate statement).

Does Mori teach that EPA DOES NOT raise LDL levels relative to a placebo group? No. It teaches there is not 95% confidence that EPA raises LDL levels relative to placebo.

What is the probability, given the DATA in Mori that EPA raises LDL levels? One can easily compute this since they report the mean and SEM.

The answer is 87.38%

Or conversely there is a ~12.6% chance that EPA does NOT raise LDL levels given the data in Mori.

These probabilities can be changed by looking at data outside of Mori, of which there is some. But not in the right Tg populations. Nor is Mori the right triglyceride population. So is it obvious? Well trying to be unbiased, w.r.t. LDL, I can maaaybee see an argument, though I tend not to agree. But with regards to ApoB and Kura, I do not see it. Combined, I do not see it.