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Re: FDApproved post# 31937

Sunday, 04/12/2020 2:08:54 PM

Sunday, April 12, 2020 2:08:54 PM

Post# of 44784

Thus, the immune response must be tightly regulated through different pathways. Uncovering the detailed mechanisms of this regulatory network is critical for understanding the pathogenesis of immune dysfunction–related diseases and developing new therapy strategies

Actually, one of the great things about MSCs is that you don't have to "uncover the regulatory network"!

MSCs are autonomous, live entities, and they respond to out of kilter conditions ("cytokine storm") by using their own normal regulatory mechanism to push the immune system toward normal homeostasis.

Understanding the underlying mechanism is important future work, and may make it possible to tweak PLX cells to function in more specific ways, but even before that, our cells will be saving millions of patients from misery and death.