NorthWest Biotherapeutics Inc (NWBO)

[791branko]

Here’s a quick list of the pros & cons to unblind the trial now -

Personally I think it time to unblind.


Reasons to continue with blind
• Assure revenue from UK Specials Program (poor TLD could stop this revenue)
• Reduce the risk of insolvency from possible poor TLD
• Allow more time for better acceptance of more flexible FDA Approval Regulations
• Allow all trial patients to pass 5-year milestone from surgery and enrollment (note, Merke combo trial scheduled to run for 6 years)
• Increase TLD maturity for MGMT methylated subgroup (mOS likely > 38months)
• Increase pressure on FDA to intervene (look at TLD)


Reasons to unblind
• Bring treatment to patients earlier
• Recognize treatment revenue earlier
• Reduce capital raises at distressed prices
• Aid advancing this science by studying the unblinded data
• Move with new L & Direct trials
• Increase the prospects of partnerships or buyouts
• Recognize a potentially much higher share price
• After more than a decade it’s simply time