NorthWest Biotherapeutics Inc (NWBO)

[DocLee]

Colchicine to prevent a cytokine storm is risky. The rationale is that:

1] a cytokine storm is due to uncontrolled release of cytokines in an inflammatory response to the infection.
&
2] Colchicine suppresses the inflammatory response in gout, therefore it might help prevent a cytokine storm.

However, as reported widely over the last few weeks, and picked up by President Macron (of France), the Chinese experience of treating Corvid-19 patients with ibuprofen (a much milder anti-inflammatory agent) was that it may increase mortality (based on 4 patients!!).