I asked that question in a recent telecon with LG. He could (would?) not say. He could not inform what the percentage of nGBM M+ MES was from his reading of the literature. He could not expand upon the trials conducted by UCLA where LL/RP suggested that MES--generally-- was especially well treated by the vaccine without distinguishing between M+/M-. He allowed that M+/MES is longer lived which is correct but did not know what percentage it is of the M+ population. He was completely unaware of the Feb. 2018 abstract in the iHub message board preamble that categorizes molecular sub groups in M+/M-. In this context, he could not address the abstract's categorisation of M+ being composed almost exclusively by pro-neural. He could not explain exactly why DC VAX L was efficacious in M- MES. I pointed out to him that LL found that MES generally was more immunogenic similar to melanoma where there was a higher residual TIL population to build upon and a less immunosuppressive micro-tumour environment. Is that correct I asked. He avoided a direct response and he said that we would know the answer to my queries when they unblind.
I told him that if they really have something interesting why wait till April 18 when the SP is in the toilet and surely a financing will be required between now and then. If he announces financing now, without "interesting" news, the SP goes in the toilet and pisses everybody off. You need to come out NOW. The market is betting more of the same and that "interesting" is a bait and switch. He responded that they will not announce anything until they are ready. What more do you need to be ready???? Is the SAP final? Did you data lock? When? Is there anything to a mid-May date that DI mentioned to an MB member? Is that when TLD will be announced? He allowed that he is not saying it won't be announced earlier but he will not say one way or the other.
In conclusion, I told him that many investors who bought into the series B/D-2 warrants 2 years ago fully expected they would be in the money by now. Now they are in danger of worthless expiry. Is that how you reward loyal supporters that help your financing needs---like me???Your waiting for the right moment and continued silence have placed the company, SP and investors in this spot. Stop referring to the nefarious forces as the cause and excuse of the collapse of the SP. The best thing you could do is come out with what is "interesting" NOW and get these warrants in the money rather than using the lure of extension to raise more money. We are all fed up with this ploy. If you don't know what is "interesting" I will give you a hint--elephant in the room. End of conversation, FWIW.
