NorthWest Biotherapeutics Inc (NWBO)

[skitahoe]

While I don't believe that 5 years is necessary, not in a disease where typically the percentage alive at 5 years can be counted on the fingers of one hand. If however you're right, I think the company would be far better off in saying that after discussions with the regulators, that is the case.

I don't believe there is anything special about 5 years. I noted in another trial they used 49 months, I have no idea how they arrived at that number, but that's what they announced. We're now well past 4 years for the last being dosed, but well beyond 5 for the majority in the trial. For all we know we may have some patients alive for over a decade. When top line data is announced, we should learn what's actually the case, but we do know that the median for the top 100 continues to grow, so more than 50 people remain alive beyond the median, which was nearly 60 months the last time it was presented by Dr. Liau, I'm guessing over 6 months ago. Once only 50 are alive, and they're all beyond the median, the median will no longer move up. If only 50 were alive, it would probably be five times what would have been expected beyond 60 months, what do you have to do to prove something is working.

Gary