Anavex Life Sciences Corp (AVXL)

[sokol]

“Placebos Can Also Produce Side Effects
Conversely, individuals can experience negative symptoms as a response to a placebo, a response that is sometimes referred to as the "nocebo effect." For example, a patient might report having headaches, nausea or dizziness in response to a placebo.”

How the Placebo Effect Works in Psychology
By Kendra Cherry Reviewed by Amy Morin, LCSW Updated on January 13, 2020

https://www.verywellmind.com/what-is-the-placebo-effect-2795466

I doubt it will hurt the clinical trial. I would argue too that untreated patients and treated patients still do not know if they are taking a placebo or AVXL 2-73. Not all patients taking the actual drug have side effects, and some patients taking the placebo do have side effects. There is no evidence the patients have been informed about what they are taking. Even before the MacFarlane statement patients taking the placebo and experiencing side effects believed he or she has taken the real thing, and those patients taking the real thing that do not experience side effects may conclude they have not been administered AVXL 2-73.