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Friday, January 31, 2020 12:21:06 PM
Dr. Craig Hofmeister M.D., of the Winship Cancer Institute in the Department of Hematology and Medical Oncology at Emory University School of Medicine stated, "I think that carfilzomib promotes pelareorep infection by suppressing the innate antiviral response and our data suggest that it does not get in the way of T-cell activation. Pelareorep infection, not proteasome inhibition, can upregulate PD-L1 expression on myeloma cells and the adaptive immune system can then assist in clearing infected tumor cells. The combination in fact enhances the body's immune attack on infected myeloma cells."
https://www.oncolyticsbiotech.com/press-releases/insights/detail/2514/kol-call-highlights-pelareoreps-unique-ability-to-activate
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