NorthWest Biotherapeutics Inc (NWBO)

[iwasadiver]

Most Big Pharma use formulations and rarely, if ever, think, let alone venture, outside the box. Their speciality is selling the treatment and sometimes perhaps perfecting the technology via further trials. I don’t believe any scientist or physician who’s seen these blinded/blended numbers could remotely dismiss what they’re seeing. I have not seen one article in the press or through the scientific community that has specifically pointed out a negative perspective on this trial after the published paper came out. The only one I’m aware of was a German Physician/researcher who stated he felt they should not have put out the paper to the scientific community because there was not enough evidence while still blinded for Physicians to make decisions about using the treatment. That’s it as far as I can find. I see no one saying anything of this sort:

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Is it because BP evaluated the platform and found it wanting, that the results of the trial are underwhelming? E.g., primary/secondary endpoints achievements have either likely failed or are not undeniable? That there is a long tail but made up overwhelmingly of M+ and that a broad approval is felt rather unlikely. Or that long tail results are for some reason not undeniable?

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No, Keytruda, the darling of the Cancer world, was approved based on a 12-15% response for a specific biomarker. The results were small, for a specific cancer, but it was essentially a “CURE” for those people who would have eventually died much sooner. The brilliance of Keytruda is the the speed and agility by which it went forward from there to other indications, all of which still represent only a “Tail of Survivability” for certain markers. It will be the expansion of DCVax in this same manner, and I believe in a much larger percentage of the cancer genome, that will be the game changing aspect of DCVax, including Direct.

It’s a simple numbers game. I believe Big P knows precisely what NWBO has, and now they can’t afford it and will be only able to do partnerships if even that. I believe Dr. Duffy came to NWBO precisely for that reason. Do you really believe the Executives at Merck or BMY know anything about the science of other companies without it being spoon fed to them by consultant scientists? I would bet my entire holdings in NWBO Big P is scoffing at Linda Power’s hold out on price. It’s in their genetics as haughty execs to poo poo other’s they consider lesser than themselves. Ego has led to uncountable ruin throughout history, all the while watched in disbelief by others who clearly saw things differently.