Anavex Life Sciences Corp (AVXL)

[sokol]

Every clinical trial that has ever been conducted begin with an hypotheses and a hope. Hypotheses are necessary and nothing new has ever been accomplished without hope. Hope is necessary because absent hope nothing will be tried - no action will be taken.

Controvesy and doubt exist in every instant where a new hypothesis is being tested. Innumerable examples exist. Take smallpox by way of only one example.

https://www.tandfonline.com/doi/abs/10.1179/isr.2001.26.2.125

“From its introduction in 1798, smallpox vaccination was always the subject of fierce controversy, particularly in England, where waning immunity from the first vaccinations coincided with government attempts to enforce compulsory vaccination. Unfortunately some supporters of vaccination tended to exaggerate its safety and benefits, while opponents equally played up the dangers and failures. Although some critics had legitimate concerns about safety and the duration of immunity, others denied that vaccination had any value at all, and claimed that its only effects were dangerous. This story has been told many times as a battle between government interference and growing demands for freedom of the individual from an increasingly articulate public – an early manifestation of the 'nanny state' and reaction against it...”

It seems that some things never change. Despite the value of vaccinations for society as a whole, we continue to witness opposition to vaccinations to this very day. Some of the diseases that we thought were elimated are beginning to recur because of the refusal of parents to vaccinate their children based on some beliefs that vaccinations are dangerous, etc.

Returning to the subject of treating AD, the hypothesis that has repeatedly failed so far is one based on amyloid plaque removal. However, this hypothesis remains based on hope that one day it will somehow be proven to be effective in some sort of clinical trial. We will have to wait and see about this, and we will have to wait and see about whether Anavex’s hypothesis bears fruit in treating CNS diseases, including AD and others. In the meantime, we must have hope, or we may abandon an hypothesis that proves to be beneficial. In my opinion, I think we should be thankful that Pasteur and others did not in the face of fierece criticism abandon their theories about vaccinations.