Amarin Corp Plc (AMRN)

[Whalatane]

JL ..Whats my point ?

1) EVAPORATE is studying those with known atherosclerosis ...defined as narrowing of at least 20% in one coronary artery . Patients with prior MI or stroke etc are excluded .
So this is a purely primary prevention study ....do you agree ?

2) EVAPORATE is using multi detector CTA ...a highly reproducible and noninvasive methodology to examine plaque burden , composition , volume , distribution etc AND can differentiate between calcified and non calcified plaque .

So now we have an accepted noninvasive way to detect changes in the coronary plaques ...something most over 50 with no prior events but with known risk factors would probably be interested in .

So if a multi detector CTA scan shows extensive coronary plaque BUT not enough to require stenting or bypass .....is Vascepa

1) Preventing these plaques from becoming calcified .
So far we are seeing an 89% reduction in calcified plaque progression . Why is this important . Because calcified plaques often prevent the proper deployment of stents therefore leaving the patient with bypass ( CABG ) surgery as the only option.
If we find out that Vascepa slows progression , but does not stop it ...but does however prevent these plaques from calcifying , that I think is important information . Rotoblation and the new ShockWave technology are approaches to deal with calcified plaque but the first has risks and the second is not approved for wide use in the US yet.
So knowing if Vascepa prevents calcification of existing plaques is important IMHO.

2) Is Vascepa halting progression ...so far we are seeing slowing of progression ...ie a 42% reduction in total plaque progression . I agree with you re rupture of plaques causing MI's but isn't Angina the result of restricted blood flow to the heart caused by large plaque deposits ...correct of necessary .
So I think its huge news if Vascepa actually halts progression of plaque development .

I agree that thicker caps making the plaques less likely to rupture is key. I however would like to know also if Vascepa is halting the development of these plaques and preventing the existing plaques from being calcified.
I think its a huge marketing tool for Amarin if Vascepa is shown to have those benefits
JMO
Kiwi