Anavex Life Sciences Corp (AVXL)

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146 weeks - MMSE declines by ~ 1.6 points (Putting it in perspective)

From a study showing how MMSE scores decline once a person contracts Alzheimer's disease:

In contrast, the MMS declined an average of 2.15 points per year (95% CI 1.85-2.46) during the first two years, accelerated to 3.83 points per year (95% CI 3.28-4.38) during the subsequent three years and then slowed to an annual decline of 1.63 points during the last two years (95% CI 0.21-3.05). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014643/

The MMSE test has a maximum of 30 (30 being perfect). Typically, a score of 24 or greater indicates normal cognition. A score of 19 to 23 indicates mild impairment. A score of 10-18 is moderate impairment. And any score below 10 is severe impairment.

The average length of time someone lives who gets Alzheimer's disease is ~4.5 years if diagnosed after age 70. The average MMSE for people diagnosed with Alzheimers is around 24 to 26. These patients if not treated can expect their MMSE score to decline by 4.3 in the first 2 years. They would be more forgetful and start to forget some names and have trouble doing various things. In the next 2 years (4 years total), their MMSE would decline another 7.66 points. They would be down a total of 11.96 points. By this time, the average person won't be able to drive and will need someone to watch them. They are moderately impaired and can still do things on their own - just not complex tasks. They will begin forgetting who their friends were and won't recall common facts. Can't be trusted with their finances. In the next couple of years (total of 6 after diagnosis) if they live that long, the average person will become severely impaired and MMSE will have decline by 15.63. Can't cook, will start forgetting everything in their life. Quality of life near zero.

Consider that in three years, Anavex 2-73 data for high concentrations show a decline of about ~ 1.6 and an even smaller decline in ADCS (Activities of Daily Living Inventory). A smaller drop in ADCS is consistent with the brain and person learning to compensate for loss of cognitive ability. I.e., learning to spend more time and think harder about activities, write down important things and etc., If the trend continues, by 6 years, their would be a drop of 3.3 and by 9 years, there would be a drop of 4.8.

What does this mean? It means that the average person who gets Alzheimer's after age 70 who takes a high dose of AVXL 2-73 would be able to live out their life until death still remembering their life while being able to live on their own if they are otherwise healthy enough to do so.

It is not a complete cure - but enough of one that people can keep their dignity until death.

For those who have earlier onset Alzheimers disease (before age 70), on average they live 10 to 12 years.

For those people, if not treated would end up needing comprehensive care after 5 or 6 years until death. They will live to forget their entire life.

If AVXL 2-73 works as well on these type patients, they would have many additional years of good life and would probably still die remembering the majority of their life, friends and relatives.