Anavex Life Sciences Corp (AVXL)

[sokol]

This article supports Missling’s hypothesis that activating SR-1 results in homeostasis that, in turn, should lead one to believe that SR-1 agonist, AVXL 2-73 et al, may indeed benefit multiple CNS diseases as well as other disorders.

“Thus, the new finding of Tsai et al. suggests that the Sig-1R apparently provides the myristic acid, by means of myristic acid “hitchhiking” on the Sig-1R that allows p35 to bind to the lipid membrane where p35 can accomplish the balanced or homeostatic activation of cdk5. This ultimately results in the regulation of normal axonal growth and maintenance......

Neurodegenerative diseases are linked to tauopathy as a result of cyclin dependent kinase 5 (cdk5) binding to its p25 activator instead of its p35 activator and becoming over-activated. The overactive complex stimulates the hyperphosphorylation of tau proteins, leading to neurofibrillary tangles (NFTs) and stunting axon growth and development. It is known that the sigma-1 receptor (Sig-1R), an endoplasmic reticulum chaperone, can be involved in axon growth by promoting neurite sprouting through nerve growth factor (NGF) and tropomyosin receptor kinase B (TrkB)[1, 2]. It has also been previously demonstrated that a Sig-1R deficiency impairs the process of neurogenesis by causing a down-regulation of N-methyl-D-aspartate receptors (NMDARs)[3]. The recent study by Tsai et al. sought to understand the relationship between Sig-1R and tauopathy[4]. It was discovered that the Sig-1R helps maintain proper tau phosphorylation and axon development by facilitating p35 myristoylation and promoting p35 turnover. Neurons that had the Sig-1R knocked down exhibited shortened axons and higher levels of phosphorylated tau proteins compared to control neurons. Here we discuss these recent findings on the role of Sig-1R in tauopathy and highlight the newly presented physiological consequences of the Sig-1R-lipid interaction, helping to understand the close relationship between lipids and neurodegeneration.....

Neurodegenerative and CNS diseases, such as Alzheimer’s disease and Parkinson’s disease, are in part caused by disturbances in proper axonal maintenance and can be recognized by a decrease in axonal length[5–7]. ...”

Activation of Sig-1R “...ultimately results in the regulation of normal axonal growth and maintenance......

AVXL 2-73 may benefit a variety of CNS diseases. Additionally, AVXL 2-73 could very well be a homeostatic anti-aging drug. Neurodegenerative diseases are associated with aging.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827442/