Amarin Corp Plc (AMRN)

[jessellivermore]

chemist....

Clearly AA/EPA is the correct determiner of systemic inflammation (SI) and therapeutic benefit...

EPA and AA (arachidonic acid..an omega-6) compete for eicosanoid receptors on the cell membrane of all cells except red blood cells (RBCs)...Both EPA and AA increase SI by generating active molecules, prostaglandins, leukotrienes, and thromboxanes...Its just that AA interactions with these receptors is much more pro inflammatory and EPA's interactions are less pro inflammatory....The competition is is one to one as far as affinity for the receptors so it breaks down to the number of EPA molecules verses the number of AA molecules..

The reason it is called systemic inflammation is the system is not confined to certain areas or locales but is the same on all cells... You can have high EPA and still have high SI if you have equally high AA...

":>) JL