Anavex Life Sciences Corp (AVXL)

[georgejjl]

The sigma-1 and muscarinic receptors have also been implicated in neurodegenerative diseases by acting as general modulators of many cellular mechanisms, including microglial regulation, mitochondrial dysfunction, oxidative damage, and endoplasmic reticulum stress. A mixed sigma-1/muscarinic receptor antagonist (ANAVEX 2-73) has been shown to prevent mitochondrial dysfunction (and the resulting oxidative damage) and reduce tau hyperphosphorylation and beta-amyloid accumulation in the brains of Alzheimer’s mouse models.

https://www.biospace.com/article/insight-report-potential-therapeutic-targets-for-alzheimer-s/

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