Aurinia Pharmaceuticals Inc (AUPH)

[CoolG73]

Regarding the Dosage Response, High Dose VCS had a better CR in the second 24 month than Low Dose since we jumped from 20% to 40% (20% increase) versus 33% to 49% (16% increase). now why is it 20% ? coz the High Dose had a 25% relapse after the first 24 months due to increased AEs that took it from 27% to 20% (in other words, those 25% were responders that discontinued the trial because of the increased side effects). this means VCS responds to increased dosage, but looks like it takes it some time to do so(24 to 48 months instead of 0 to 24 months). the 23.7 dose was not chosen because it is more potent that the 39 dose but because of the side effects and increased AEs.