Anavex Life Sciences Corp (AVXL)

[XenaLives]

Someone asked me about 2-73 and stroke recovery. My response:


I think it's more than likely it could be used to treat and mitigate damage from strokes. Also it could be used to improve CV health in those at risk for strokes, preventing some strokes.

Some posts on the subject:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150898494
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151322544
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150987107

Too much Glutamate? (from makemydaze)

An excess of glutamate is a primary contributing factor to a wide variety of neurological disorders like autism, ALS, Parkinson’s schizophrenia, migraines, restless leg syndrome, Tourette’s, pandas, fibromyalgia, multiple sclerosis, Huntington’s chorea, and seizures. As well as atrial fibrillation, insomnia, bedwetting, hyperactivity, OCD, bipolar disorder, anxiety disorders, and STIMS (repetitive self-stimulatory behaviors like rocking, pacing, body spinning, hand-flapping, lining up or spinning toys, echolalia, repeating rote phrases or other repetitive body movements or movement of objects that are commonly seen in autistic children), stiff person syndrome, and an increased risk of stroke.

https://www.holistichelp.net/blog/how-to-increase-gaba-and-balance-glutamate/

Statins, NSAIDS and antidepressants can increase risk for stroke, 2-73 could reduce or eliminate the use of these drugs:
https://www.mdedge.com/neurology/article/107470/stroke/commonly-prescribed-drugs-may-increase-risk-stroke

Inflammation, autophagy and gut microbiota involved in stroke mechanism.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151136991

Anavex 2-73 is a sigma-1 receptor agonist. A chaperone protein, sigma-1 is activated in response to acute and chronic cellular stressors, several which are important in neurodegeneration. The sigma-1 receptor is found on neurons and glia in many areas of the central nervous system. It modulates several processes implicated in neurodegenerative diseases, including glutamate and calcium activity, reaction to oxidative stress, and mitochondrial function. There is some evidence that sigma-1 receptor activation can induce neuronal regrowth and functional recovery after stroke. It also appears to play a role in helping cells clear misfolded proteins – a pathway that makes it an attractive drug target in Alzheimer’s disease, as well as other neurodegenerative diseases with aberrant proteins, such as Parkinson’s and Huntington’s diseases.

https://investorshub.advfn.com/boards/read_msg.aspx?message_id=150450481