Amarin Corp Plc (AMRN)

[jessellivermore]

sstyles...

The current problem is not generic Diabetes Mellitus...The epidemic is Type 2 Diabetes Melitis...I am sure you understand Juvenile diabetes is caused by protein abnormaties in the Beta cells of the pancreas..which interfere with Calcium transfer and results in lack of production of insulin...

The real epidemic T2DM is not the result of lack of insulin..but the fact the sugar lowering activity of the insulin produced is reduced so that more insulin needs to be produced to obtain the same sugar lowering effect..This lack of activity is called Insulin Resistance (IR) and it is been proven to be caused by elevated Systemic inflammation (SI)..And there is no controversy about this causal relation...Though there is a lot of ignorance on the part of clinicians..

The root problem is elevated SI which leads to IR which results in high insulin levels..Insulin has many effects other than lowering sugar...Among other things, insulin facilitiates (is a catalyst) for the the production of Arachidonic Acid (AA) which is which in competition for cell membrane eicosanoid receptors..Which are present on every cell in the body other than Red blood cells.. Increasing AA levels effects the EPA/AA ratio and elevates SI...

I have found through experience that most diabetics and their physicians are unaware of this viscous cycle..

Doubt this...Go back to the ACCORD clinical trial..ACCORD was a complicated trial with three separate endpoints..One of the endpoints was to test importance of maintaining strict control of the A1C levels..ACCORD was halted when it became apparent there were more fatalities in the group that maintained the low A1Cs than in the control..A paradox...The reason for this was the arm which maintained the low A1Cs was being controlled by using insulin...

The problem with T2DM is elevated SI...something that very few Diabetic doctor seem aware of...IR the major problem in T2DM is a marker for elevated SI...The reason why Vascepa is so effective in lowering CVD events in T2DM is that EPA increase the EPA/AA ratio and this lowers SI which then lowers IR...The real problem in T2DM is elevated SI and it is the key to dealing with T2DM...

":>) JL...