Amarin Corp Plc (AMRN)

[sharinky]

There are instructions for statins "To maximize the effects of statins with a short half-life, statins such as fluvastatin, lovastatin, and simvastatin should be dosed at bedtime allowing the greatest drug concentration to be present during peak endogenous cholesterol synthesis."

Cholesterol production in the liver is highest after midnight and lowest during the morning and early afternoon, so statins are most effective when taken just before bedtime.