Sunday, September 22, 2019 5:57:08 PM
Very interesting information regarding the role of exosomes, produced in neurons, to communicate or control external nerve or neuron processes. Most important is the report that selected, exogenous (external) exosomes can restore or promote proper neuron growth and function. Restoration or promotion of normal nerve function — significant implications for all Central Nervous System diseases and conditions.
In the case of exosome dysfunction (and consequent CNS disease), might that be often caused by poorly synthesized proteins within the exosome? Might those development-controlling proteins be mis-formed if their sites of final topology (shape, folding) in the endoplasmic reticulum were compromised by the lack of a normal endogenous sigma-1 receptor agonist or a related chaperone?
It is now well understood that Anavex 2-73 restores, facilitates proper protein folding in the endoplasmic reticulum. Properly-folded proteins (primarily as functional enzymes) control biochemical reactions. If mis-folded in the neuron, cellular chemistry goes awry; nerve pathology results (CNS disease).
Is there, then, the possibility that Anavex 2-73 so facilitates normalized exosome production that all of the downstream processes they control function normally? Might this be the mechanism by which Anavex 2-73 (or other Anavex sigma-1 receptor agonists) might have such a wide, diverse set of positive therapeutic results for a diversity of otherwise unconnected CNS and other diseases?
I’ve contended previously that the Anavex drugs will not be confined to just Rett, Parkinson’s Disease Dementia, or Alzheimer’s; the three diseases now in clinical trial. The Anavex pipeline displays a number of other diseases and conditions that will be targeted. I’m certain that Anavex has tested their molecules against a host of diseases in murines (rats and mice). It will be surprising if in the next several years a good number of other diseases and conditions are not clinically targeted.
Lastly, how much of geriatric decline is caused by exosome dysfunction? As we age, is exosome function compromised, resulting in any or all of the debilities of older age? If so, what, then, might be the implications of prophylactic administration of Anavex 2-73, to facilitate the suitable production of functioning exosomes, to slow the aging process (if that might be possible)?
Let’s watch. The Anavex story is still in the first chapter.
Recent AVXL News
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- Anavex Life Sciences Corporation Class Action: The Gross Law Firm Reminds Anavex Life Sciences Investors of the Pending Class Action Lawsuit with a Lead Plaintiff Deadline of May 13, 2024 - AVXL • PR Newswire (US) • 04/05/2024 09:45:00 AM
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- Investors who lost money on Anavex Life Sciences Corporation(AVXL) should contact The Gross Law Firm about pending Class Action - AVXL • PR Newswire (US) • 03/26/2024 09:45:00 AM
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- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 02/23/2024 11:05:18 AM
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- Form SC 13G/A - Statement of acquisition of beneficial ownership by individuals: [Amend] • Edgar (US Regulatory) • 01/25/2024 10:01:34 PM
- Anavex Life Sciences Reports Publication of ANAVEX®3-71 in Clinical Journal Confirming Pharmacokinetic Dose Proportionality of ANAVEX®3-71 in Humans • GlobeNewswire Inc. • 01/24/2024 12:30:00 PM
- Anavex Life Sciences Announces U.S. Phase 2 Clinical Trial of ANAVEX®3-71 in Schizophrenia • GlobeNewswire Inc. • 01/16/2024 12:30:00 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 01/13/2024 01:00:34 AM
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