Notes from Janney presentation.
I listened to the first 11 minutes of the recorded presentation, looking for interesting items, and I wanted to record exactly Dr.Ms description of autophagy.
Exact Dr.M quotes are in quotes.
My comments and questions are in parentheses.
Going into 4th year of observing dosing of patients with AD (P2A 32coh.)
---(I wonder if there is any other AD drug with 3 years of AD data, except Donepezil? Also, can they be varying the dose? Of course, not higher than current max.)
Sufficient cash for all objectives beyond the next 24 months.
---(I think he means to 24months)
Next Catalysts:
* Rett Study top line data
* PD P2 Demential study top line data
* Clinical data publication of AD P2A "information which has been presented at various scientific meetings."
---(It sounds like this is the peer reviewed study. I hope it is more than what has already been presented. Maybe it ties theories together including gut microbiota.)
* In discussions to and explore, new indications with our approach, as well as looking at licensing opportunities.
---(New indications could be ERP, or gut signals or something totally new. Implied the licensing is after top line data. Licensing separate bullet?)
...All these diseases have in common Rett, PD, AZ and autism, they all have extensive cellular stress in the body.
---(Wow Autism has made it up to his top 4 to be mentioned. Autism is huge!)
This cellular stress must be addressed, and the body uses the Sigma1 receptor. When the S1 receptor is constantly requested to reduce the stress, it become overused or not sufficiently available any more.
So added S1 activation is needed and that can be given from the outside. And that is what A2-73 is doing. A2-73 provides added stimulation of the S1 gene and S1 protein to do its job.
The beneficial effects, and this has been published, are:
* reduces tau
* high postulation of tau (not sure I got this right...chemistry is not my first language!)
* reduce protein misfolding
* reduces inflammation
* restores mitochondrial dysfunction
In a publication in March of this year, ..."A2-73 has demonstrated to activate an impaired autophagy which is a key clearance process of CNS neurons which cannot just get rid of trash which accumulates in the cells. Because there is no exit for those cells.
The only way the cell can survive is by triggering or activating this recycling process and that is called autophagy."
The publication demonstrated that A2-73 enhanced the autophagy process in animals and cellular experiments, and the animal had extended life and longevity.
