Doc logic Wednesday, 09/11/19 11:19:51 PM Re: survivor1x post# 243778 Post # of 244450 survivor1x, Matured DCs are required for mobility to the lymph zone in the skin of the upper arms which in L's case is away from the tumor draining lymph nodes in or near the brain that are heavily influenced by the compromised signaling caused by the cancer itself. The actual maturation/activation process for L starts off similarly ex vivo so yes, the teenagers pick up the antigens in the lysate like Direct would do en vivo but then are matured so that the information gathered can be mobilized to move into the lymph zone instead of remaining at the site of injection and dying or all being killed off by a process called phagocytosis. There are other things that were learned from Direct Phase 1, though, that may have played a part in any "optimization". Not to worry, NWBO has some smart cookies that have figured out how to use the valuable information these trials have generated. Best wishes.