Amarin Corp Plc (AMRN)

[Atom0aks]

I did read them both. Now is your turn. Remember, you're an evidence guy, you like to ask everyone for evidence.

Now it is your turn to show your wisdom (a link =/= wisdom).

I anxiously await your calculations.

Source: https://www.nejm.org/doi/pdf/10.1056/NEJMoa1812792?articleTools=true

In REDUCE-IT, the risk of the primary composite end point of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization, or unstable angina, assessed in a time-to-event analysis, was significantly lower, by 25%, among the patients who received 2 g of icosapent ethyl twice daily than among those who received placebo, corresponding to an absolute between-group difference of 4.8 percentage points in the rate of the end point and a number needed to treat of 21.

Using calculations provided here, https://bestpractice.bmj.com/info/us/toolkit/learn-ebm/how-to-calculate-risk/

AR (absolute risk) = the number of events (good or bad) in treated or control groups, divided by the number of people in that group
ARC = the AR of events in the control group
ART = the AR of events in the treatment group
ARR (absolute risk reduction) = ARC – ART

Applying data provided in Figure 4, https://www.nejm.org/doi/pdf/10.1056/NEJMoa1812792?articleTools=true
ARC = 901
ART = 705
ARR = 901 - 705 = 196

196/4098 (number of people in the treatment group) = 0.0478 (4.8%)

Make sense?