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The Sigma-1 Receptor in Cellular Stress Signaling.
Hayashi T1.
Author information
1
Seiwakai Nishikawa Hospital, Hamada, Japan.
Abstract
After decades of research, the sigma-1 receptor (Sig-1R)'s structure, and molecular functions are being unveiled. Sig-1R is an integral endoplasmic reticulum (ER) membrane protein which forms an oligomer and binds a variety of psychotropic drugs. It forms a complex with the ER chaperone BiP that controls specific signaling molecules' stability and function at the ER to regulate Ca2+ signaling, bioenergetics, and ER stress. Sig-1R is highly enriched in ER subdomains that are physically linked to outer mitochondrial membranes, reflecting its role in regulating ER-mitochondria communications. Thus, Sig-1R ligands are expected to serve as novel neuroprotective agents which treat certain psychiatric and neurodegenerative disorders. In this short review, the cell biological aspects of Sig-1R are discussed, with a particular focus on its role in fundamental ER functions.

https://www.ncbi.nlm.nih.gov/pubmed/31379486

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