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seventhwave

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seventhwave

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Saturday, 08/03/2019 11:07:23 PM

Saturday, August 03, 2019 11:07:23 PM

Post# of 461849
If strong efficacy/dose response to blood concentration of A2-73 (or its metabolite) has been firmly established and the big hurdle (that's making us all sweat) is metabolite gut absorption specificity for which the bulk of biomarkers are being established, has anyone asked the question...

Why don't we do a trial for an A2-73/19-144 patch (eg. on arm) and dodge the whole gut absorption issue?

19-144 is probably a nano-molecule which crosses the blood-brain barrier - surely its readily absorbed through the skin. A patch is a much better dispensation method for the geriatric population.

Is part of the treatment also happening in the gut?

Humor me through this.
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