Marker Therapeutics Inc (MRKR)

[hanscott]

Here is a CR where the patient was in a clinical trial testing a pancreatic cancer vaccine called GVAX, after which the tumor actually increased. But they also had a long history of varied chemo first.

"This report describes the methodology of the patient’s treatment including the use of metronomic chemotherapy, combination chemotherapy, sequential therapies, and immunotherapy with the hope of providing a roadmap toward the successful treatment of this deadly cancer, and perhaps other cancers.

The patient then enrolled in a phase 2B clinical trial (NCT02004262) in early-July 2015 that investigated if the efficacy of a GVAX pancreatic cancer vaccine given with low-dose cyclophosphamide and live attenuated Listeria monocytogenes engineered to express mesothelin in previously treated patients with a histologically proven malignant adenocarcinoma of the pancreas. The patient was in the treatment arm that received 6 doses of modified Listeria alone. She participated in this clinical trial until a repeat CT scan in February 2016 revealed an increased size and number of hepatic lesions. Corresponding blood work showed her CA 19-9 had increased to 16,311."

http://pancreas.imedpub.com/elevenyear-survival-with-unresectable-metastatic-pancreaticcarcinoma-a-roadmap-to-longterm-survival-for-metastatic-disease.php?aid=21001

----------------