Marker Therapeutics Inc (MRKR)

[poods]

I think they are using MAPP. Unless I a mistaken, Survivn may be the only TAA expressed in high concentration in pancreatic Ca. However, that is based on my own research and MRKR may well have contradicting data. For example, some of the cancer testis antigens being used are expressed on pancreatic cancer cell lines but not detected on tumors in vivo. However, It's possible that expression could be induced by treatment. I'm quite sure we'll hear more about this at their presentation. There is clearly a lot of room for improvement of the product for pancreatic cancer with addition of more antigens in the mix (e.g. WT-1, mesothelin, MUC-1). That said, the MAPP product candidate is certified safe and can immediately be applied to other solid tumors (especially if it is working for pancreatic cancer). The fact is that other solid tumors actually express more of the antigens in MAPP than pancreatic cancer. For example melanoma express the cancer testis antigens in high concentration and 2 are actually named because of there high expression in melanoma (MAGE and PRAME).