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Re: Doc328 post# 200086

Monday, 07/08/2019 3:16:02 PM

Monday, July 08, 2019 3:16:02 PM

Post# of 467782
a 12 week trial for Rett - would be sufficient enough if you were to check for a 50% responder rate for improvement of seizures.

Look at the most recent phase 3 trials for Briviact, Vimpat, Aptiom, etc - all were a 12 week period before open phase study began.

If the Rett trial is to show clinically significant reduction of seizures from baseline - 12 weeks is sufficient, in my opinion.
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