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Re: Gator328 post# 196949

Tuesday, 06/18/2019 12:14:26 AM

Tuesday, June 18, 2019 12:14:26 AM

Post# of 473843
If 2-73 gets an indication for PDD, neurologists will prescribe it off label for AD. Fact is, if it gets approved for Rhetts, it will also be prescribed for AD. The AD field is essentially wide open; SOC sucks. Desperate patients and their families will plead for any opportunity; and doctors equally desperate to find something that may have, however remote or unproven, a chance to help them, are going to prescribe the drug. In fact, once given any approval the problem will be manufacture and distribution, not demand. If Australia approves for any indication, this same rationale will lead to the EU and US quickly lining up. No amount of FDA circumspection will withstand the political pressure. Mark this: any indication will prove an enormous boon, a kind force multiplier, for AVXL; phase 3 for AD will be sprinted past, and phase 4 will be the decider.
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