NorthWest Biotherapeutics Inc (NWBO)

[Extremist223]

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B7-homolog 1 expression by human glioma: a new mechanism of immune evasion

https://drive.google.com/open?id=17BPyF_5QYhXcx57F-3qrisP0T5iVdNos

Considering the correlation between B7-H1 expression and tumor grade, it is noteworthy that vascular endothelial growth factor (VEGF) was shown to increase the expression of B7-H1 by tumor cells [16]. VEGF is recognized as a key factor in glioma angiogenesis and is overexpressed mainly in glioblastoma in the close vicinity of necrotic areas [17]. It was also shown that VEGF might impair adequate presentation of tumor antigens by inhibiting the maturation of dendritic cells [18]. The stronger expression of B7-H1 in glioblastoma observed in our study suggests that VEGF may exert additional negative effects on the anti-tumor response by modifying the expression of immunoregulatory molecules on the surface of tumor cells.