NorthWest Biotherapeutics Inc (NWBO)

[Lykiri]

Meirluc,

I have compared all curves (2017 and 2018) and this is my final conclusion:

Data 2017

108 patients alive. 68 patients alive between month 18 and month 36 and 40 patients alive beyond month 36.

12 LTFU = 5 methylated LTFU between month 0 and month 18, 5 unmethylated LTFU between month 0 and month 18 and 2 "unknown" LTFU (censor 4 and censor 46 on Sentiment curve: https://investorshub.advfn.com/uimage/uploads/2018/10/22/gddzjCombined_charts_no_notes_revised_-lykiri.jpg ).

207 patients died between month 0 and month 36, 3 patients died between month 36 and month 37 and 1 died probably around month 88.

Total number of patients who died ( March 2017) : 207+3+1= 211.

211 (dead) + 12 LTFU + 108 alive = 331 ITT.

Data 2018.

Of the original 12 LTFU, 5 are still LTFU and censored between month 0 and month 14 .

7 of the original 12 LTFU were found dead. You can find them all(7) when you analyze every step down on the OS curve NOV.2018. (I have to admit that is hard work)

Of the 68 patients still alive in 2017 between month 18 and month 36 , 19 died between month 18 and month 36 and 6 out of the 68 were new LTFU. ( 1 is censored around month 23, 1 is censored around month 24 , 1 is censored around month 30 an 3 are censored between month 35 and month 36).

I strongly believe that 4 of the hashmarks just prior to the 3 year line will be found alive at month 36 when they do the final data lock.

That will bring the total of patients at risk at month 36 = 91 (87 + 4).

Between month 36 and month 37 you can see 5 or 6 steps down on the OS curve Nov. 2018.

On the OS curve 2017 there are 3 steps down between month 36 and month 37. That means that 2 or 3 patients of that last group of 43 patients (87-44) died between month 36 and month 37.

So, we are sure that 19 patients died between month 18 and month 36, 2 or 3 died between month 36 and month 37 an probably the 2 new censored patients around month 23 and month 24 will be found dead when they do the final analyses.

19 + 2 (or 3) + 2 LTFU= 23 or 24 patients out of 108 alive March 2017 died between month 18 and month 37.(these patients died between March 2017 and Oct.2018)

We don't know how the patients are doing who lived beyond month 37.
I believe that the majority of these patients are still alive today.
IMO, most of these patients are patients with no tumor reocurrence and i think the other patients are pseudo PFS.

I found evidence for this opinion here:

-Video presentation Linda Liau 2015, 2016 and 2019.
-Comment of Linda Liau after the publication of the 2017 interim data.
-Interview Linda Liau Magazine Spring 2018.
-Interview Linda Liau June 2018.
-Marnix Bosch Asco presentation 2018.
-Presentation Linda Powers Jan.2019.
-OS curves 2017 and 2018 + a lot of data.
-Some PR's from the compagny.

Conclusion: IMO it is possible that around 74 patients are still alive today.

Some additional information about the 19 patients out of 108 who died between month 18 and month 36:

6 patients are methylated. (3 died between month 24 and month 30 and 3 died between month 30 and month 36)

13 patients are unmethylated. (3 died between month 18 and month 24 , 6 died between month 24 and month 30 and 4 died between month 30 and month 36)

I advise every long to analyze all OS curves. IMO you will discover additional interesting information.