Sunday, May 05, 2019 9:22:21 AM
It is significant because it strongly indicates DCVax-L vaccine has indeed done its job what it is designed and intended to -- its Mechanism of Cction (MOA) is confirmed, by prolonging patients PFS living and then hopefully OS as well.
And it can only be done by mobilizing killer cells to attack residual cancer cells after vaccine administration, and mobilizing killer cells whenever new cancer cells are reborn, and launch attacks on these newly generated cancer cells due to memory. As a result, it can prolong both PFS and OS of patients who have received the vaccine.
And it is important that the results are absolutely not by a chance, because the existing of such a significant proportion of PFS patients has not been seen for those patients who have received the current standard of care or those from Optune trials.
Indeed, as many have readily pointed out it also busts the long persistent short theory of trial failure at a perceived interim analysis.
Of course, the trial needs to be unblinded to have a definite conclusion.
[Just realize this post is not specific to your post antihama]
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