Aurinia Pharmaceuticals Inc (AUPH)

[moosedogger]

Jess, on second thought this is so complex I think the thing to do is to try to talk with Neil for a few minutes and ask him if VCS is possibly a viable treatment for SLE.

This excerpt puzzles me: "At week 48, more than one-half of the subjects in the placebo group (53.4%) still had SELENA-SLEDAI scores >6 compared with 29.2% and 40.9% in the low- and high-dose VCS groups, respectively. Although the improvements in the SELENA-SLEDAI scores were primarily due to improvements in the renal components, when extrarenal elements were assessed alone, the VCS groups tended to have a similar or greater reduction in activity than did the control group (Supplementary Figure S4). For example, the extrarenal SELENA-SLEDAI scores fell 53%, 51%, and 67% in placebo, low-dose VCS, and high-dose VCS patients at week 48,
respectively."

The above is from an article from "Kidney International Organization". Neil Solomons is one of the authors of this excellent piece, which contains a wealth of info on AURA.

https://www.kidney-international.org/article/S0085-2538(18)30628-8/fulltext