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Re: Lima4918 post# 189482

Saturday, 04/13/2019 12:23:09 PM

Saturday, April 13, 2019 12:23:09 PM

Post# of 470070

The thing is that there is efficacy well past 148 weeks, just ask Mislsing or just watch Kaufman's actions.

When I saw that he was presenting this 148 week data a lightbulb started flickering in my head. That "aha" moment when you think that this drug is showing efficacy for years....



AVXL investors should also keep in mind that our leadership team is now playing on a more level field than might have been the case in the past. The A2-73 science and precision medicine practices being applied by AVXL should accomplish two things. The processes present reduced time required to confidently achieve waypoints and reduced risk of failure associated with past unknown variables (as pointed out by CMO earlier w/the "one size fits all" approach.). Use of strong Biomarker evidence (right population) from linked w/closer trials monitors, like Actigraph in PDD, all stack up to close monitoring and execution. Risks of failure are considerably lower w/these techniques, more like verification of an expected result (given the laws of chemistry and biology) vs. trial and error. The tradition of trial results over time is not what they are now speaking to. They speak w/confidence about the next waypoint on a long cross country flight. As pilots in command they understand they will have turbulence but (barring in flight emergency) they are certain to get to the destination. Risks will have been significantly mitigated by flight monitors and controls along the way.
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