NorthWest Biotherapeutics Inc (NWBO)

[flipper44]

It's the difference between a more artificial solution versus a more natural solution.

With CIs (and Car-Ts for that matter), researches are asking the antibodies (or t-cells) to do something the human evolutionary system did not design them to do. With CIs, they are taking away the ability of the body to intermittently turn off its own t-cell response, with Car-ts, they are asking the immune cells to specifically target B-cell cancer as well as healthy B-cells. Nature doesn't destroy all its healthy B cells to fight cancer.

DCVax-L instead reminds the immune system not to be put to sleep by cancer's signaling, and develops the best and the brightest DCs to instruct the t-cells to go after the tumor targets. Nature developed a lock and key selection system, and DCVax-l leverages that system by getting the tumor and non-suppressed DCs together outside the body. After vaccine, the patient response, when it occurs, is typically a reawakened (aka: not suppressed) immune system that stops/stabalizes cancer.

CIs are essentially akin to putting soldiers on duty 24/7 with no rest to attack first and ask questions later...."oops, sorry about your kidneys, arthritis, etc....my bad....yawn... got any coffee?"

DCVax-L is essentially akin to generals and soldiers doing their job through thoughtful coordination/communication without being tricked into ignoring danger. Your body is fighting potential cancer every day. No big deal. Typically it will isolate and slowly rid the body of precancerous foes. DCVax-L, when it works, takes care of cancer within the bounds of your immune system's evolutionary playbook.