Amarin Corp Plc (AMRN)

[IgnoranceIsBliss]

Hey, you know I've been on vacation for a while and didn't participate in discussions here about the Total Events analysis paper.

We missed you really badly. I mean REALLY badly. OMG it was so bad. It was like one of those planets where the Jedi knights leave and don't come back for a LONG time.

I had to go look up "legacy effects" in a pharma context to make sure what it meant. Looks like technically it's changes that endure after the trial regimen is over. I think it's supposed to be what other durable benefits people got even if they don't stay on the drug long-term. But perhaps it includes long-term effects one way or the other.

Anyhow -- we have the hints already, don't we? All the other indications we've been bandying about here on Tattooine (dry eye, weight loss, Alzheimers, NAFLD, other cognitive stuff, superpowers like seeing around corners and being able to tell when someone is lying, etc). I don't want to get my hopes up TOO high because it has felt a little like they've been promising the moon on these big presentations and then we only get a large asteroid. We're really spoiled now, you know.

On the per protocol front, obviously what we want to see is a really strong correlation between usage and efficacy for Vascepa, but there's also the back-door mineral oil conspiracy theory killer here -- which is compliance on the placebo side. If mineral oil really were blocking statins, then you should see a really crappy RRR when comparing compliant placebo people with non-compliant people, right? (By compliant, I mean taking everything. If people kept taking the statin but not the trial drug, that doesn't help us.)

Last thing -- any opinion on the likelihood of updates to ACC and AHA guidelines? There was a sense that that only happens every 5 years, but my internet surfing tells me there are mechanisms for interim updates. ADA did have ACC review their work on the ADA update... is that a hint?